Dr Shevin Jacob is corresponding author on a perspective piece published in the New England Journal of Medicine calling for universal standards of care to be applied in relation to Ebola Virus Disease
Antibiotic resistance is an emerging global public health threat spurred by the overuse and misuse of antibiotics. While "overuse" of antibiotics is widely accepted as a major health challenge
Estradiol is a commonly prescribed estrogen therapy. Previous research has found that rats treated with the hormone experience an increase in sugar consumption
Marie Kondo herself couldn't do it any better. Usually cells are good at recognizing what doesn't spark joy. They're constantly cleaning house -- picking through their own stuff to clear out what no longer works.
Here’s everything we know about legal weed and the way it’s changing our roadways.
Here’s how an apology can go a long way after a medical error.
World's largest study of deep brain stimulation in the brain's reward system Study with 16 participants with previously treatment-resistant depression shows excellent results over one year Results published in the journal Neuropsychopharmacology Patients suffering from severe, treatment-resistant depression can benefit not only acutely but also the long-term from deep brain stimulation, as researchers from the Medical Center - University of Freiburg and their colleagues from the University Hospital Bonn demonstrate in a current study. The team used thin electrodes to stimulate a deep seated part of the reward system in the brains of 16 patients. This led to a significant reduction of ratings of depression severity in all patients, it was reduced by half on average. For half of the study participants it was even reduced below the level regarded as the threshold for a depression requiring treatment. Most of the patients experienced those positive stimulation effects within the first week, and they lasted throughout the course of the one-year study. The study was published online in the Nature journal Neuropsychopharmacology on Thursday, 14 March 2019. "The most compelling outcome from the study is the sustained efficacy in very severely ill patients. Most treatments in psychiatry cease to be efficacious after moths and years, we demonstrated for the first time in demonstrating in a relatively large-scale study that deep brain stimulation is a real option for those patients suffering from treatment-resistant, severe depression," says group leader Prof. Dr. Thomas Schläpfer, head of the Division of Interventional Biological Psychiatry at the Medical Center - University of Freiburg. Success after Dozens of Unsuccessful Treatments An estimated 10 to 30 percent of all people with recurring depression do not respond to approved treatments. Deep brain stimulation could be a treatment option for some of these patients. The 16 participants in the FORSEE-II study had suffered from severe depression for 8 to 22 years and had previously undergone an average of 18 drug therapies, 20 electroconvulsive therapies, and 70 hours of psychotherapy - without success. Prof. Dr. Volker A. Coenen, first author of the study and director of the Stereotactic and Functional Neurosurgery Unit at the Department of Neurosurgery of the Medical Center - University of Freiburg, and his team implanted the deep brain stimulation systems in the patients medial forebrain bundle of the brain and used them to stimulate the medial forebrain bundle. This brain region is involved in the perception and regulation of pleasure and reward and is thus also significant for motivation and the perceived quality of life. Clear Relief Often within Days The doctors evaluated the success of the therapy monthly with the help of the established Montgomery-Asberg Depression Rating Scale (MADRS). The MADRS scores of ten study participants already decreased significantly within the first week and remained at a low level. All study participants reacted to the stimulation in the course of the study. Eight of the 16 patients had a MADRS score of under 10 points at the end of the study and thus were regarded as non-depressive. "Our patients had struggled with severe depression for years with no signs of improvement. Deep brain stimulation brought most of them significant relief within days, which lasted throughout the course of the therapy. Other forms of treatment like medication and psychotherapy often lose their effectiveness over the course of time. Absolutely sensational about the study data is that the effect seems to be long lasting, with the positive effects continuing for years", says Prof. Schläpfer. "We know from a pilot study that the stimulation of this brain region is very promising and we are delighted about the replication of these significant effects," says Prof. Coenen. Hopes for European Approval of the Method On the basis of the results of the just-published study, the Freiburg researchers already began work on their third study (FORESEE-III) in October 2018. It will involve the treatment of 50 severely depressed patients. Fifteen patients have already been operated. "If the follow-up study is as successful as the current one, we have high hopes for receiving European approval of the method," says Prof. Schläpfer.
'Gamified' new rehab therapy helps severely impaired stroke survivors regain arm mobility
Patients receiving hormone therapy as part of their gender-transition treatment had an elevated risk for cardiovascular events, including strokes, heart attacks and blood clots, according to a study published in the American Heart Association's journal Circulation.
Developed by researchers at the University of Turku in Finland, an immunotherapeutic antibody therapy re-educates macrophages to activate passivated cytotoxic T cells to kill cancer.
Promising new therapies for food allergies are on the horizon, including experimental immunotherapy awaiting federal approval that enables people who are very allergic to eat peanut protein without suffering serious side effects.
Nonsense mutations are single-letter errors in the genetic code that prematurely halt the production of critical proteins.
Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment.
A new clinical practice guideline from the American Academy of Sleep Medicine (AASM) provides guidance to clinicians on the use of positive airway pressure (PAP) therapy to treat obstructive sleep apnea (OSA) in adults.
Frequency of these relapse dreams decreases as the body and brain adapt to abstinence
Researchers from the University of Sheffield School of Health and Related Research (ScHARR) are today making a series of recommendations for NHS mental health trusts to change the way they collect and use patient feedback to improve the quality of care for inpatients.