High Dosages Of Vitamin C Can Kill Colorectal Cancer Cells
Vitamin C has long been tested to boost immune system and help the body restore tissues thus helping it cope with aging. A recent study published in the health journal Science would further affirm the benefits of Vitamin C especially in curing cancer.
In the study conducted by Lewis Cantley Weill Cornel Medicine and their team in New York, it has been found out that Vitamin C destroys mutated cells with KRAS and BRAF genes that can lead to the formation of colorectal cancer, TechTimes reported.
A high dose of Vitamin C is further proven to prevent the growth of tumors among the tested mice in the study.
As observed, when cells absorbed Vitamin C, cancer cells underwent oxidative stress that inhibits the production of more enzymes that can cause cancer.
"High-dose vitamin C impaired tumor growth in Apc/KrasG12D mutant mice. These results provide a mechanistic rationale for exploring the therapeutic use of vitamin C for CRCs with KRAS or BRAF mutations," the researchers said in their study.
'Oxidative stress' happens when part of the Vitamin C absorbed in our arteries are converted to dehydroascorbic acid (DHA) and antioxidants try to revert DHA to ascorbic acid which results in the death of the mutated cells, according to University Herald.
"More than half of human colorectal cancers carry either KRAS or BRAF mutations, and are often refractory to approved targeted therapies. We report that cultured colorectal cancer cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C," the researchers wrote in their abstract.
The potency of taking high dosage of Vitamin C in treating cancers like colon, liver, prostate, pancreatic, started in the 1970s as recorded by the National Cancer Institute. However, despite the numerous studies about this, real data supporting the potency of Vitamin C has not been produced yet, Nature World Report said.