A Noncoding RNA Promotes Pediatric Bone Cancer: Study
A long noncoding RNA named Ewing sarcoma-associated transcript (EWSAT1) is critical target of the fusion protein, according to a new study.
It also contributes to the complex network of changes that occur in the Ewing Sarcoma - a cancer of bone or its surrounding soft tissue that primarily affects children and young adults.
A team led by Alejandro Sweet-Cordero at Stanford University identified increased expression of EWSAT1 in cancer cells from children with Ewing sarcoma. Further they showed that this noncoding RNA is important for cancer cell growth and associated with the repression of several genes downstream of EWS-FLI1, the press release said.
The study supports the idea that long noncoding RNAs can be key drivers of cancer and identifies an important mediator of Ewing Sarcoma.
The study was published in the Journal of Clinical Investigation.