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PSA Rise With Testosterone Gel Associated With Specific Factors

Update Date: Nov 12, 2014 12:16 PM EST

Factors that predict greater prostate-specific antigen (PSA) increase with use of testosterone gel (T-gel) include age 60 years and older, baseline testosterone (T) ≤250 ng/dL, and percentage of free PSA <20 percent, a new study has found. 

Researchers evaluated more than 250 hypogonadal adult men with baseline T concentrations <300 ng/dL, PSA ≤2.5 ng/mL, and a negative digital rectal examination. Subjects were randomized to receive either once-daily T-gel for T therapy or placebo.

Researchers noted that baseline mean T values were 247 ng/dL and mean PSA levels were 0.9 ng/ML. The mean percentage of free PSA was calculated 24.6. 

"Among men treated with T-gel, there were increases in T and PSA (P = 0.0012). Compared to baseline, in the placebo group, T increased, while PSA decreased. The PSA increase was greater in men 60 years and older than in men younger than 60 years (P = 0.0006). Mean PSA only changed in men with baseline T ≤250 ng/dL (P = 0.0031). In men with baseline %fPSA <20 percent, PSA increased 0.3 ng/mL, while it increased 0.1 ng/mL in men with %fPSA ≥20 percent," the press release said. 

"Overall, T-gel treatment was associated with a minor increase in PSA, of questionable clinical significance," the authors wrote. "Men with T >250 ng/dL and age <60 years demonstrated minimal or no PSA change."

The study was published in Journal of Sexual Medicine. 

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