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Researchers Develop Safer, Cheaper Building Blocks For Future anti-HIV and Cancer Drugs

Update Date: Jul 04, 2014 09:03 AM EDT

A team of researchers has developed an economical, reliable and heavy metal-free chemical reaction yielding fully functional 1,2,3-triazoles - chemical compounds that can be used as building blocks for more complex chemical compounds like pharmaceutical drugs. 

Up until now for synthesizing the compound, manufactures had to be dependent on harmful heavy metals to work which limited their biological applications. 

In the new study, researchers reported for the first time 1,2,3-triazoles can be synthesized through metal-free, three-component reaction using readily available ingredients. 

"We were able to develop a reaction that provided a good yield, high regioselectivity and easy access to diversely functionalized 1,2,3-triazoles," said corresponding author Prof. Dr. Wim Dehaen, in the press release. "In other words, the reaction produces plenty of the compounds we're looking for, does so reliably without unwanted or unexpected outcomes, and does this in a way that makes it easy for us to isolate the compound. This makes our method highly desirable."

"Moving forward, we will focus on expanding the chemistry developed here to other new reactions while also exploring their possible applications in pharmaceutical as well as supra-molecular sciences," added lead author Dr. Joice Thomas.

The experiments have been reported in the journal Angewandte Chemie. 

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