Diseased DNA Found Throughout the Body
Faulty DNA that increase the risk of hereditary disease are floating everywhere in the human body, according to a new study.
Using network biology to model interactions between proteins associated with diseases such as Parkinson's in different tissues, researchers found that genes associated with hereditary disease are sprinkled throughout the human body.
Researchers explained that these network proteins trigger unique interactions relevant for the mechanism of the disease in tissues vulnerable to hereditary disease.
Researchers explain that genes associated with disease tend to be more highly expressed. The latest study revealed that many examples of tissue-specific protein interaction highlighting disease mechanisms. Because disease-causing genes are rare compared to other genes, researchers said the latest study shows that they can be used as a powerful filter for understanding the origins of disease.
The findings are published in the journal PLOS Computational Biology.