Mental Health

Lower Iron Levels Seen in Newborns of Obese Mothers

By Staff Reporter | Update Date: Jul 09, 2012 11:43 AM EDT

According to new research, children born to obese mothers face health problems stemming from the womb.

Researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and The Mother Infant Research Institute at Tufts Medical Center claim that lower iron levels are being seen in newborns of obese mothers.

Researchers looked at 15 obese pregnant women with body mass index (BMI) greater than 30 and 15 healthy weight pregnant women with BMIs between 20 and 25. Maternal blood draws took place during the second trimester of pregnancy and newborn iron status was measured in cord blood.

The researchers found that being born to an obese mother with elevated hepcidin levels was associated with lower iron status at birth. Obese adults are known to produce higher levels of hepcidin compared to healthy weight adults and the researchers suggest that overproduction of the hormone interferes with the transfer of iron from mother to infant. The results were recently published online by the Journal of Perinatology.

When there is excess hepcidin in a cell, it binds to and inhibits the function of ferroportin, the protein that allows iron to pass through the cell membrane and into the bloodstream," said Senior Author Simin Nikbin Meydani.

According to the researchers, more research is needed before any changes to dietary guidelines or recommendations to obese pregnant women should be considered. Most prenatal vitamin supplements contain 27 milligrams of iron, the daily amount currently recommended by The American Congress of Obstetricians and Gynecologists.

"During pregnancy, women should try to eat a varied, healthy diet while taking the standard prenatal vitamins recommended by their doctors," said First Author Sarbattama Sen. "Weight gain goals should be based on a woman's BMI prior to becoming pregnant. In 2009, the Institute of Medicine issued new guidelines on weight gain during pregnancy."

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